Applying computational approaches to immunogen selection and modification has set new standards in vaccine design. Consider codon optimization, a method which allowed scientists to circumvent codon usage bias in order to achieve high levels of difficult-to-express proteins outside their native hosts. Codon optimization has helped immensely in the development of HIV prototype vaccines where viral genes (gag, env, pol etc.) were expressed in the absence of the Rev-RRE system.
Achieving efficient expression of a...
Monday, 21 February 2011
It all started with EpiMatrix...
By
biohive
Monday, February 21, 2011
computational immunology
,
de-immunization
,
epitopes
,
gene
,
vaccines
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Tuesday, 8 February 2011
Immune Design steps up and gets noticed…again...and again!
By
biohive
Tuesday, February 08, 2011
adjuvant
,
dendritic cell
,
HIV
,
lentivirus
,
vaccines
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Back in July, Immune Design raised $32 million in a Series B financing; that’s quite a bit of money and brings the total up to $50 million since 2008. Amongst the leading investors we can see ProQuest Investments (who also have in their portfolio companies like Aerovance, who develops asthma-combating drugs, and Somalogic, who develops novel diagnostics tools for oncology, neurology and CV diseases), The Column Group, Versant Ventures and Alta Partners.Now the company is making waves once again by...